VP, High-Throughput Chemistry
As Vice President of High Throughput Chemistry, Eray leads insitro’s efforts in collection of data correlating molecular structures with biological activities.
Eray is a scientist and inventor with a passion for DNA Encoded Libraries and other invitro evolution technologies. He joined insitro from Haystack Sciences where he was a co-founder, and CEO. His innovations in the DEL field include greatly expanding the synthetic diversity achievable with evolvable DELs, and devising the nDexer selection platform. Prior to Haystack, Eray built and screened DELs at Impossible Foods, and in the lab of Pehr Harbury at Stanford. He did a post-doc at Vanderbilt University in the pharmacology department, working with Anthony Forster, Craig Lindsley, and Borden Lacy. His graduate work in the lab of Chaitan Khosla focused on precursor-directed biosynthesis of novel polyketides, and also on the discovery of novel dihydroisoxazoles targeting TG2 for treatment of Celiac disease.
Eray’s hobbies include science fiction of all kinds, and spending summer Saturdays at the river.
Fio is a cheminformatics scientist in the drug discovery team focusing on supporting the design and generation of massive datasets to enable machine learning driven drug discovery.
She obtained her Ph.D. in theoretical chemistry at the laboratory of cheminformatics in Strasbourg. Afterwards, she joined the Computer-Aided Drug Design team at Novartis Institutes for BioMedical Research as a postdoctoral scholar. Following that, she worked at DiCE Molecules, a DNA-encoded library start-up.
Fio enjoys running and hiking in the beautiful redwood forests and is passionate about arts and crafts.
Jacob is an associate scientist on the high-throughput chemistry team. He received his BS in molecular synthesis from UC San Diego and has experience in medicinal chemistry.
Prior to Insitro he worked at Crinetics Pharmaceuticals synthesizing small molecule drug candidates for rare endocrine diseases.
In his free time Jacob enjoys going to the beach and hiking with his dog, cooking and eating all sorts of things, and watching any professional sport he can find
Keith James, SVP of Drug Discovery
SVP of Drug Discovery
Keith James, SVP of Drug Discovery
As Senior Vice-President of Drug Discovery, Keith is responsible for machine learning-enabled drug discovery programs at insitro. Keith and his team are both establishing new drug design capabilities, exploiting the power of machine learning models, and undertaking drug discovery programs on molecular targets derived via the insitro-human (ISH) target discovery platform.
Keith has over three decades of drug discovery experience, building and leading research enterprises ranging from handfuls to hundreds of scientists, tackling programs across a wide range of therapeutic areas, and employing a panoply of therapeutic modalities. During his career, Keith, and the organizations he has led, have delivered over thirty clinical candidates, across fifteen therapeutic areas, many of which have reached Phase 2, and two of which are in the hands of physicians treating patients today – eletriptan (Relpax®) for migraines and maraviroc (Selzentry®) for HIV infections.
Before joining insitro, Keith was President of the Ferring Research Institute in San Diego, engaged in the discovery of peptide therapeutics. Before joining Ferring, Keith had a long career at Pfizer, leading discovery research at three different sites across the US and UK, heading the company’s R&D strategy team, and running a laboratory as a visiting investigator at The Scripps Research Institute.
Keith completed his academic and postdoctoral studies at Imperial College London, The University of Cambridge (Raphael lab), Stanford University (Johnson lab), and Columbia University (Stork lab).
In his free time, Keith enjoys cycling, jogging, reading, writing and mechanical watches.
Nikhil is a biochemist with experience in membrane protein expression, purification, structural biology. During his PhD from IIT Kanpur in India, Nikhil worked on biochemical structural and functional aspects of small GTPases.
He has experience in working in diverse biomedical fields including Microbial genetics, structural biology and Biochemistry. As a postdoctoral scientist in Michigan State University and Baylor College of Medicine, Nikhil worked on the structural basis of ribosome assembly using Bacillus subtilis as a model system. As a staff-scientist in Baylor College of Medicine, Nikhil worked on structural and biochemical aspects of membrane protein of Norovirus. Before joining insitro, he was working on biochemistry of Human NADPH Oxidase as a staff-scientist in St. Judes children’s research hospital.
In his free time, Nikhil enjoys playing with his kids and outdoor photography.
Patrick is a chemical biologist with experience in DNA encoded library synthesis, selection and assay development.
He obtained his Ph.D. in chemistry from Yale University in the Spiegel lab. His graduate research focused on using chemistry to influence the immune system and led to the development of a fully synthetic antibody mimetic. For his postdoctoral work in the Kodadek lab at Scripps Florida he focused on solid-phase DNA encoded library development, synthesis and selections through fluorescent activated cell sorting. He joined Haystack Sciences in 2018 and has developed and optimized the nDexer selection platform.
Patrick uses most of his spare time to read good science fiction books, watch bad science fiction movies, collect paintings and visit national parks.
Victor Galievsky is a spectroscopist with experience in studying kinetic reactions, including biomolecular affinity interactions. At insitro, Victor designs kinetic electrophoresis techniques for the ‘smart’ separation of small molecules and proteins.
Before insitro, Victor worked with Prof. Sergey Krylov (York University, Toronto) and Prof. Janusz Pawliszyn (University of Waterloo, Waterloo) in Canada. His research focused on developing capillary electrophoresis and microfluidic devices to obtain exceptional analyte detectability. Victor coupled a solid-phase microextraction (SPME) sampling with optical detection and created a new in vivo SPME point-of-care analysis approach.
Victor obtained his Ph.D. in laser physics and spectroscopy from the Institute of Physics of the National Academy of Sciences of Belarus (Minsk, Belarus). He also worked as a visiting scientist at the Institute of Physical Chemistry (Warsaw, Poland) and the MPI for Biophysical Chemistry (Göttingen, Germany). Victor’s initial work focused on developing time-resolved spectrometers and their implementation to investigate the specific interactions between porphyrins and nucleic acids, the energy and charge transfer reactions in donor/acceptor molecules, and the photosensitized singlet oxygen generation.
In his free time, Victor enjoys hiking, traveling and photography.